Once you reach agency level 8 you unlock a special Global Conflicts mode that lets you send Agents out on special missions. This guide will tell you How To Get Region Keys In Agents Of Mayhem so you can progress to new regions and unlock vastly better rewards.
Before you are able to do this you must first reach level 8 with your Agency. Once you’ve done so you can go to Operations and use the Global Conflict mode. This feature lets you send your Agents on various missions around the world to unlock items. Initially you only have access to East Asia, a region that contains 4 different areas that you can explore.
If you want to unlock Region Keys you have to complete a region. You need to send an Agent to each of the areas within a region and successfully complete the mission there. Once your Agent has returned from each of the missions you will be rewarded with a Region Key that you can use to unlock a new region.